Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
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چکیده
منابع مشابه
P 107: P2x7 Receptors: as a Novel Targets for the Treatment of Neuroinflammation
P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tu...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2020
ISSN: 1359-4184,1476-5578
DOI: 10.1038/s41380-020-00965-3